| Issue 14: | More regression models / Sigmoid regression / EC50 | |
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Please describe the purpose and the intended behaviour of the new feature. Most biological reaction follow a Sigmoidal/LogSigmoidal regression. Creating tool to calculate such regression such as EC50, Min, Max etc. would be great. If it has connection to other parts please state it too. I wanted to devellop such library but I don't know enough about KNIME to do it (in addition, I was having problem to get some of the HITS source code to use as a base). For this I wanted to use Michael Thomas Flanagan's Java Scientific Library (http://www.ee.ucl.ac.uk/~mflanaga/java/ need to get permission to redistribute) which provides the tools to calculate Ec50 etc. An other resource that could work is: www.ncgc.nih.gov/pub/openhts/curvefit. Note that it would be nice to be able to get this EC50 on sets with replicates and for multiple features measured. For instance if you have a table as follow: CompoundID;[Concentration];Value1;ValueX;etc A;1;3;5;... A;1;2;4;... A;10;15;30;... A;10;18;27;... B;... to obtain an EC50 (or other parameters of the sigmoid) for each of the compounds. I think part of this can be done using KNIME nodes provided with Hits, but the Sigmoid or other type of regression and there plotting does not exist. Perhaps this could be done?
May 8, 2009
Project Member
#1
aborgabor
Labels:
Component-Logic
May 8, 2009
Thanks for the answer. I will ask at the KNIME user forum. |