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Motifs
Motifs for RnaO discussion
IntroductionThese are motifs that we would like to agree on definitions for. MotifsA minor RNA motif (SO:0000022)SO def: "A region forming a motif, composed of adenines, where the minor groove edges are inserted into the minor groove of another helix." [SO:ke] hammerhead ribozyme (SO:0000380)SO def: "A small catalytic RNA motif that catalyzes self-cleavage reaction. Its name comes from its secondary structure which resembles a carpenter's hammer. The hammerhead ribozyme is involved in the replication of some viroid and some satellite RNAs." http://rnaworld.bio.ku.edu/class/RNA/RNA00/RNA_World_3.html asymmetric RNA internal loop (SO:0000021)SO def: "An internal RNA loop where one of the strands includes more bases than the corresponding region on the other strand." [SO:ke] K turn RNA motif (SO:0000023)SO def: "The kink turn (K-turn) is an RNA structural motif that creates a sharp (~120 degree) bend between two continuous helices." [SO:ke] also in FR3D: cWW-tSH-tWH-tHS-cWW_kink-turn also in FR3D: cWW-tSH-tSH-tHS-cWW_kink-turn sarcin like RNA motif (SO:0000024)SO def: "A loop in ribosomal RNA containing the sites of attack for ricin and sarcin." http:////proton.chem.yale.edu/pdf/7897662.pdf also in FR3D: cWW-tSH-tHW-tHH-cWW_sarcin-like symmetric RNA internal loop (SO:0000025)SO def: "An internal RNA loop where the extent of the loop on both stands is the same size." [SO:ke] RNA junction loop (SO:0000026)no SO def. RNA hook turn (SO:0000027)no SO def. C-loopcWW-tHW-cSW-cWW sarcin/ricin motif(contrast sarcin like RNA motif above (SO:0000024)) cWW-tSH-tHW-cSH-tHH-tHS-cWW cWW-tWH-insertion-tHS-cWWGAAA-receptorcWW-tWH-cWW cWW-(cWW-cSW)-(tWH-cWW)-cWW-cWWcWW-tSH-tWH-tHS-cWWcWW-tHS-cWWcWW-tSH-tHS-cWWcWW-tSH-tSH-tHS-cWWcWW-tSH-tSH-tHS-tHS-cWWcWW-tWH-tSH-tHS-cWWcWW-cWS-cWWcWW-(cWH-cWW)-(tHW-cWW)-cWWcWW-cSH-cWW-tHS-cWWinsertion-ccWW-tSH-tHH-cSH-tWH-tHS GNRA tetraloopUNCG tetraloopT-loopcWW-tSH-tSW (hairpin loop)CUCAA (hairpin loop) |
In light of our conversations on desiring a way for people who know nothing about a GNRA tetraloop to learn about it, I dug up this: http://en.wikipedia.org/wiki/Tetraloop
ROC Multiple Sequence Alignment Working Group Paper and Multiple Sequence Alignment Relations discussed by Rob Knight: http://rna.bgsu.edu/ROC