This is the x86-64 build of Notepad2

If you find any issues specific to the x86-64 build, report them!

FAQ

Why are my program settings not saved at all?

Notepad2 requires write access to the ini-file to be able to save the program settings. If settings are saved manually (F7), a warning message appears if the ini-file is write-protected. However, on exit, no warning is issued, as setting the read-only flag of the ini-file can be used to freeze the settings.

On Vista and above, Notepad2 is not allowed to write files inside the %PROGRAMFILES% directory tree, by default. You need to move the Notepad2.ini file to your %APPDATA% directory (type %APPDATA% into the Windows Explorer address bar to locate it), or manually edit the Notepad2.ini file inside the program directory (requires elevated privileges) and add the following text right at the top:

[Notepad2]
Notepad2.ini=%APPDATA%\Notepad2.ini

This will move the Notepad2.ini file to your user profile directory.

Source: http://www.flos-freeware.ch/doc/notepad2-FAQs.html