About Us

GO-Elite is an open-source software project principally run by developers in the Bruce Conklin laboratory at the J. David Gladstone Institutes and the University of California San Francisco. GO-Elite has been developed as a component of the GenMAPP suite of applications. The focus of GO-Elite is to provide biologists with an easy to use tool to assess over-representation of Gene Ontology terms and pathways from genomics datasets. Beyond over-representation analysis (ORA), GO-Elite identifies a minimal set of non-redundant Gene Ontology terms, allows users to efficiently identify genes associated with each term and customize queries. GO-Elite is funded by an NIH RO1 grant (ARRA Suppl. GM080223-06S1).

GO-Elite provides annotations for nearly any species (over 50 species supported) or gene system, with the ability to easily add species and gene system support. GO-Elite's default database supports all gene systems provided by the Ensembl database, including various microarray manufacturers (Affymetrix, CodeLink, Illumina, Agilent). In addition to a stand-alone program, GO-Elite has an accessible web-interface, webservice and a plugin for the program Cytoscape. If you would like to contribute to GO-Elite development or to the documentation on this site, we welcome your contributions.

Citing GO-Elite

The following citations are most relevant:

Alternative splicing regulates mouse embryonic stem cell pluripotency and differentiation. Salomonis N, Schlieve CR, Pereira L, Wahlquist C, Colas A, Zambon AC, Vranizan K, Spindler MJ, Pico AR, Cline MS, Clark TA, Williams A, Blume JE, Samal E, Mercola M, Merrill BJ, Conklin BR. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10514-9. Epub 2010 May 24.

Alternative splicing in the differentiation of human embryonic stem cells into cardiac precursors. Salomonis N, Nelson B, Vranizan K, Pico AR, Hanspers K, Kuchinsky A, Ta L, Mercola M, Conklin BR. PLoS Comput Biol. 2009 Nov;5(11):e1000553. Epub 2009 Nov 6.

Other Articles

Canadian Bioinformatics News letter feature

Articles citing GO-Elite

Development Team