Open Science project on domain family expansion
Some domain families of similar function have expanded more than others during evolution. By expansion it is meant changes in the number of domain instances for each domain type. Different domain families might have significantly different constraints imposed by their fold that could explain these differences. This project aims to understand what properties determine these differences focusing in particular on peptide binding domains. Examples of constraints to explore include average cost of production or capacity to generate binding diversity for the domain family.
This project is also a test for using Google Code as a research project management system for open science. Wiki pages will be used to collect previous research and milestone discoveries during the project development and to write the final manuscript towards the end of the project. Issue tracking system can be used to organize the required project tasks and assign them to participants. The file repository can hold the datasets and code used to derive any result.
This project is open to anyone interested in the subject that would be interested in contributing. Have a look at the wiki and pending issues and send an email to pedrobeltrao@gmail.com with the type of analysis/literature research that you would be interested in contributing with.
