BUGSModelLibrary is a prototype PKPD model library for use with WinBUGS 1.4.3. The current version includes:

• Specific linear compartmental models:
• One compartment model with first order absorption
• Two compartment model with elimination from and first order absorption into central compartment
• General linear compartmental model described by a matrix exponential
• General compartmental model described by a system of first order ODEs

The models and data format are based on NONMEM/NMTRAN/PREDPP conventions including:

• Recursive calculation of model predictions
• This permits piecewise constant covariate values
• Bolus or constant rate inputs into any compartment
• Handles single dose, multiple dose and steady-state dosing histories
• Implemented NMTRAN data items include:
• TIME, EVID, CMT, AMT, RATE, ADDL, II, SS

The library provides BUGS language functions that calculate amounts in each compartment. BUGSModelLibrary is an active, open-source project of Metrum Institute (http://metruminstitute.org).