AfterLogic XMail Server Lite provides SMTP/POP3 services, AJAX webmail, multiple domains and accounts, virtual domains, spam filter, and lots of other features.
AfterLogic XMail Server Lite is distributed under GPLv2 license and is available for Linux (Unix) and Windows. Windows edition comes with ASP.NET webmail/webadmin frontend, Linux edition includes PHP version of these components.
AfterLogic XMail Server Lite page can be found at: http://www.afterlogic.com/products/xmail-server-lite
The commercial version with extended functionality (AfterLogic XMail Server Pro) is also available at: http://www.afterlogic.com/products/xmail-server-pro